Effects of Cyclopentolate on Form Deprivation Myopia in Guinea Pigs
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چکیده
منابع مشابه
Effects of Cyclopentolate on Form Deprivation Myopia in Guinea Pigs
Purpose: To investigate the effects of intravitreal injection of cyclopentolate on form deprivation myopia in guinea pigs. Methods: Thirty-five guinea pigs at age of 3 weeks were randomly divided into 5 groups (n = 7 for each group): deprived, deprived plus saline, deprived plus cyclopentolate, normal control, and cyclopentolate group. Form deprivation was only performed in right eyes with tran...
متن کاملChanges in muscarinic acetylcholine receptor expression in form deprivation myopia in guinea pigs.
PURPOSE Muscarinic receptor signaling is involved in ocular development and implicated in myopia. The aims of this study were to identify the presence of muscarinic acetylcholine receptors (mAChRs) in normal ocular tissues of guinea pigs and to determine if ocular expression of mRNA and protein changes in guinea pigs with or without form-deprived myopia (FDM). METHODS One- to two-week-old gui...
متن کاملGABAB Receptor Antagonist CGP46381 Inhibits Form-Deprivation Myopia Development in Guinea Pigs
The aim was to investigate the effects of the GABAB receptor antagonist, CGP46381, on form-deprivation myopia (FDM) in guinea pigs. Twenty-four guinea pigs had monocular visual deprivation induced using a diffuser for 11 days (day 14 to 25). The deprived eyes were treated with daily subconjunctival injections (100 μl) of either 2% CGP46381, 0.2% CGP46381, or saline or received no injection. The...
متن کاملForm-deprivation myopia in the guinea pig (Cavia porcellus)
Form deprivation (FD) was induced in 61 guinea pigs with a diffuser worn on one eye. The form-deprived eye elongated and developed myopia within 6 days in animals raised under a 12:12 h light/dark cycle, but not when reared in darkness. After 11 days of FD, the average eye was -6.6 D more myopic and 146 microm longer than its fellow eye. Initially the myopia was mostly from vitreous chamber elo...
متن کاملThe role of cGMP in ocular growth and the development of form-deprivation myopia in guinea pigs.
PURPOSE Development of myopia is associated with remodeling of the sclera, a tissue composed principally of collagen. Cyclic guanosine monophosphate (cGMP) regulates collagen synthesis in several organs; therefore, we investigated the effects of soluble guanylyl cyclase (sGC) stimulation and inhibition on refraction and ocular growth in guinea pigs under normal and form-deprived (FD) conditions...
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ژورنال
عنوان ژورنال: Open Journal of Ophthalmology
سال: 2015
ISSN: 2165-7408,2165-7416
DOI: 10.4236/ojoph.2015.51003